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T15658 |
KH7
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cAMP
,
AChR
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KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibito... |
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T16938 |
ST034307
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Adenylyl cyclase
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ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). |
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T60003 |
AC1-IN-1
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Adenylyl cyclase
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AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM). |
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T0322 |
Fipexide
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Dopamine Receptor
,
AChR
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Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is... |
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T10066 |
2',5'-Dideoxyadenosine
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|
Adenylyl cyclase
,
Adrenergic Receptor
,
AChR
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2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM). |
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T16275 |
NB001
|
HTS 09836 |
Adenylyl cyclase
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NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain. |
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T8702 |
SKF-83566
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Dopamine Receptor
,
5-HT Receptor
,
AChR
|
|
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
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T0830 |
Bithionol
|
Actamer |
cAMP
,
Parasite
|
|
Bithionol (Actamer), formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bit... |
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T2172 |
SQ22536
|
9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536 |
AChR
|
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SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isola... |
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T80069 |
PACAP (6-27) (human, ovine, rat)
|
Pituitary adenylate cyclase-activating peptide (6-27) |
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PACAP (6-27) (human, ovine, rat) serves as an antagonist for the PACAP receptor, inhibiting the catecholamine response of the canine adrenal gland to vasoactive intestinal peptide (VIP). This compound holds promise for r... |
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TP1878 |
PACAP (1-38), human, ovine, rat
|
Pituitary Adenylate Cyclase Activating Polypeptide 38,PACAP 1-38 |
PACAP
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PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a neuropeptide with 38 amino acid residues. |
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TP1054 |
PACAP (1-38), human, ovine, rat TFA
|
Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA) |
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PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP... |
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T11918 |
Lysipressin
|
Lysine vasopressin,[Lys8]-Vasopressin |
Others
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Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. |
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T14880 |
CB-7921220
|
6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid,6-(4-Aminostyryl)picolinic acid,6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid |
AChR
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CB-7921220 (6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid) is an inhibitor of adenylate cyclase. |
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T23588 |
9-CP-Ade Mesylate
|
9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate |
AChR
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9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase. |
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T29652 |
9-Cyclopentyladenine
|
NSC19486,NSC 19486,9CPAde,9-CP-Ade,9 CP Ade,NSC-19486 |
AChR
|
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9-Cyclopentyladenine (NSC-19486) is an adenylate cyclase inhibitor that blocks cellular morphological differentiation and phosphorylation of specific signaling molecules. |
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T11918L |
Lysipressin acetate(50-57-7(fb_acetate))
|
Lysine vasopressin acetate,[Lys8]-Vasopressin acetate |
Others
|
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Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) , Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been foun... |
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T22489 |
2'-MeCCPA
|
2-Chloro-N-cyclopentyl-2′-C-methyladenosine |
HCV Protease
,
Adenosine Receptor
|
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2'-MeCCPA is a potent and highly selective A1 adenosine receptor (A1AR) agonist with a K-value of 1.8 nM for AR.2'-MeCCPA inhibits trichostatin-stimulated adenylate cyclase activity with an IC value of 13.1 nM.2'-MeCCPA ... |
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TP1844L |
Small Cardioactive Peptide B SCPB acetate
|
Small Cardioactive Peptide B SCPB acetate(84746-43-0 free base) |
Others
|
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Small Cardioactive Peptide B SCPB acetate (Small Cardioactive Peptide B SCPB acetate (84746-43-0 free base)) is a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and ... |
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T78105 |
PAC1R antagonist 1
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PACAP
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PAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasm... |
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TP1878L |
PACAP 1-38 acetate
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PACAP
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PACAP 1-38 acetate is a pituitary adenylate cyclase activating polypeptide (PACAP) analogue. PACAP 1-38 acetate binds to PACAP type I receptor(IC50 = 4 nM) and PACAP type II VIP2 receptor(IC50 = 1 nM) but not to PACAP ty... |
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T4436 |
RO1138452
|
CAY10441 |
Others
,
Prostaglandin Receptor
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|
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli... |
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T1139 |
Salbutamol
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Albuterol,AH-3365 |
Adrenergic Receptor
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Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol ... |
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T31751 |
Fce 21258
|
Ddh-carbo pgl2 |
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Fce 21258 is used to stimulate the adenylate cyclase of synovial fluid macrophages. |
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T37477 |
L-858,051 (hydrochloride)
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L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat... |
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T24365 |
L 858051
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7B-Forskolin,L858051,Dmpb-forskolin,L-858051 |
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L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes. |
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T27057 |
CP 154,526
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CP-154,526,CP154,526 |
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CP 154,526 is a selective CRF1 receptor antagonist (Ki = 2.7 nM). CP 154,526 blocks CRF-induced activation of adenylate cyclase and the HPA axis. |
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T36009 |
Guanylyl Imidodiphosphate (lithium salt)
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|
|
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Guanylyl Imidodiphosphate (lithium salt) is a non-hydrolyzable GTP analog that increases adenylate cyclase activity. |
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TP1844 |
Small Cardioactive Peptide B (SCPB)
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Small Cardioactive Peptide B SCPB |
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Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively. |
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TP1722 |
PACAP (6-38), human, ovine, rat
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|
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PACAP (6-38), human, ovine, rat is a potent antagonist of PACAP 38. PACAP (6-38) is much more potent and selective than PACAP (6-27) in the inhibition of PACAP-27-stimulated pituitary adenylate cyclase. |
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T21803 |
Guanylyl Imidodiphosphate
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|
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Guanylyl Imidodiphosphate trisodium (Guanosine 5'-[β,γ-imido]triphosphate), a non-hydrolysable GTP analogue, activates ADP-ribosylation factor (ARF) and strongly stimulates adenylate cyclase. It is utilized in protein sy... |
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T26536 |
AC-178335
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AC 178335,AC178335 |
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AC-178335 is a pure somatostatin (SRIF) antagonist with an affinity constant (Ki) of 172 +/- 12 nM. AC-178335 blocks SRIF inhibition of adenylate cyclase in vitro (IC50 = 5.1 +/- 1.4 microM). It induces GH release when g... |
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T82306 |
Glucagon (22-29)
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|
|
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Glucagon (22-29) acts as a partial agonist of Glucagon (19–29) and independently inhibits the calcium (Ca2+) pump in liver plasma membranes without activating adenylate cyclase [1] [2]. |
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T70581 |
CY208-243 Mandelate
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|
|
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CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY... |
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T36239 |
6β-Prostaglandin I1
|
6β-Prostaglandin I1 |
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6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for aden... |
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T36072 |
Skyrin
|
Endothianin,Rhodophyscin |
|
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Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor. At 10 μM, skyrin reduces both glucago... |
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T36428 |
PACAP-related Peptide (human) (trifluoroacetate salt)
|
|
PACAP
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PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adeny... |
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T36236 |
5-cis Carbaprostacyclin
|
|
|
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5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 μM compared to 0.3 μM for carbaprostacyclin. 5-cis Carbapros... |
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T38055 |
Salvinorin A Propionate
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|
|
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Salvinorin A propionate is a selective partial agonist at κ1-opioid receptors (KOR) with a Ki value of 32.6 nM. It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR. It is selective fo... |
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T76363 |
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
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[Tyr22] Calcitonin Gene Related Peptide (22-37), rat, refers to a fragment (amino acids 22-37) of the rat calcitonin gene-related peptide (CGRP) that targets the CGRP receptor and adenylate cyclase. While calcitonin is p... |
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T37435 |
PACAP-related Peptide (rat) (trifluoroacetate salt)
|
|
PACAP
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PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adeny... |
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T36775 |
13,14-dihydro Prostaglandin E1
|
13,14-dihydro Prostaglandin E1 |
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13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and wash... |
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T36427 |
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
|
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PACAP
|
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Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres... |
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T70865 |
BMY-42393
|
|
|
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BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 mic... |
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T76042 |
Angiopeptin TFA
|
|
|
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Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, acts as a partial agonist at sst 2/sst 5 receptors, exhibiting IC50 values of 0.26 nM and 6.92 nM, respectively. This compound effectively inhibits the rele... |
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T36720 |
Deacetylforskolin
|
|
|
|
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos... |
